Supercritical Fluid-Assisted Fabrication of PDA-Coated Poly (l-lactic Acid)/Curcumin Microparticles for Chemo-Photothermal Therapy of Osteosarcoma

After traditional osteosarcoma resection, recurrence of tumor is still a major clinical challenge. The combination chemotherapy and photothermal therapy (PTT) has great potential in improving therapeutic effect. However, the studies using polydopamine (PDA) as transducing agent to improve anti-cancer activity curcumin (CM)-loaded poly (l-lactic acid) (PLLA) microparticles (PLLA/CM) have seldom been investigated. In this study, we reported synthesis PDA-coated PLLA/CM (PDA-PLLA/CM) prepared by PDA coating on surface fabricated solution-enhanced dispersion supercritical CO2 (SEDS) for chemo-photothermal osteosarcoma. average particle sizes PDA-PLLA/CM with spherical shape were (802.6 ± 8.0) nm (942.5 39.5) nm, respectively. exhibited pH- near-infrared (NIR)-responsive release behavior promote CM drug delivery system. Moreover, displayed good conversion ability stability attributed coating. Additionally, results vitro experiment showed that 500 μg/mL had effect MG-63 cells no obvious toxicity MC3T3-E1 cells. incubation 2 days, NIR irradiation treatment improved obviously reduced cell viability from 47.4% 20.6%. These indicated possessed synergetic Therefore, study demonstrated may be an excellent platform tumors.